What does high mannose binding lectin mean?

A role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE.

How does mannose binding lectin work?

Mannose-binding lectin plays an important role in the body’s immune response by attaching to foreign invaders such as bacteria, viruses, or yeast and turning on (activating) the complement system .

Is MBL deficiency a primary immunodeficiency?

NOTE – This section has been rewritten by the IDF Medical Advisory Committee 5/1/16 Manose Binding Lectin Deficiency is Not a Primary Immunodeficiency Disease MBL (manose binding lectin) is a part of the lectin pathway of the complement system, one of several different components of our immune defense.

Is mannose binding lectin an antibody?

Anti-Mannose Binding Lectin antibodies are readily available from several suppliers. Mannose Binding Lectin is a reported synonym of the human protein ‘mannose binding lectin 2’, encoded by the gene MBL2. The full protein is reported to be 248 amino acid residues in length.

What is normal mannose-binding lectin in adults?

Normal serum levels of MBL range from 800 to 1000 ng/ml in healthy Caucasians, however, wide variations can occur due to point mutations in codons 52, 54 and 57 of exon 1 and/or in the promotor region of the MBL gene [3].

Is MBL deficiency an autoimmune disease?

MBL deficiency predisposes both to infection by extra-cellular pathogens and to autoimmune disease.

What triggers the lectin pathway?

The lectin pathway is initiated when pattern-recognition molecules (MBL, CL-K1, and ficolins) bind to the so-called pathogen-associated molecular patterns (PAMPs) (D-mannose, N-acetyl-D-glucosamine, or acetyl groups), on the surface of pathogens or to apoptotic or necrotic cells (9).

What is normal mannose binding lectin in adults?

What would be the consequences of deficiency in activation of C3?

Deficiency of C3, the major opsonin, results in recurrent pyogenic infections, particularly with encapsulated bacteria. Deficiencies of early classical pathway components (C1, C4, C2) do not usually predispose individuals to severe infections but are associated with autoimmune disorders, especially SLE.

Where is mannose-binding lectin found?

This protein complex plays an important role in the immune system’s response to foreign invaders (pathogens). Mannose-binding lectin recognizes and attaches (binds) to sugars, such as mannose, fucose, and glucose, that are found on the surface of bacteria, viruses, and yeast.

Where does mannose-binding lectin come from?

It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins. Expression and function in other organs were also suggested.

How do you test for MBL deficiency?

Common infections in MBL deficiency are due to viruses, e.g. influenza and bacteria, such as Pseudomonas aeruginosa and Staphylococcus aureus. The diagnosis is made using a sample of the patient’s blood. This is tested to see if the MBL protein is present in normal levels or is reduced.