What does TRPM8 stand for?
What does TRPM8 stand for?
Transient receptor potential cation channel subfamily M
Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans.
Where is TRPM8 found?
TRPM8 is a cold sensing TRP channel that is activated by chemical ligands such as menthol and icilin [70,71]. It is highly expressed in prostate tissue; however, its functional role there remains to be elucidated . TRPM8 is functionally expressed in dorsal root ganglia and trigeminal ganglia.
How does menthol activate TRPM8?
Menthol induces the sensation of cooling by activating TRPM8, an ion channel in cold-sensitive peripheral sensory neurons. Recent studies identified additional targets of menthol, including the irritant receptor, TRPA1, voltage-gated ion channels and neurotransmitter receptors.
How does cold activate TRPM8?
TRPM8 activity is low at this temperature. Middle: cold temperature or a cooling compound such as menthol (M) activates TRPM8, resulting in an inward current flow and an increase in firing frequency of cold fibres.
What is Melastatin?
From Wikipedia, the free encyclopedia. TRPM is a family of transient receptor potential ion channels (M standing for wikt:melastatin). Functional TRPM channels are believed to form tetramers. The TRPM family consists of eight different channels, TRPM1–TRPM8.
Why does menthol feel cold on skin?
Menthol triggers cold-sensitive receptors in the skin, resulting in a cooling sensation that feels super fresh. It also works its magic in the mouth, stimulating the specialized nerve endings that allow you to feel cold.
Why does menthol make you feel cold?
Your body senses cold when a protein called TRPM8 is activated in your nerve cells, which then relay a current signal to your brain that it interprets as a cold sensation. Menthol has the unique ability to activate TRPM8, tricking your nerves into thinking they’re feeling cold when they’re actually not.
Is menthol a TRPM8 antagonist?
Although some data has indicated that menthol may activate a variety of other channels, including transient receptor potential Ankyrin 1 (TRPA1), gamma-aminobutyric acid (GABA), and voltage-gated calcium and sodium channels [6,7], more recent studies have demonstrated that the prime target of menthol is indeed TRPM8.
What do TRP channels do?
TRP/TRPL channels are solely responsible for depolarization of insect photoreceptor plasma membrane in response to light. When these channels open, they allow sodium and calcium to enter the cell down the concentration gradient, which depolarizes the membrane.
What does menthol do to the brain?
Adding menthol to nicotine increased the “communication” between a brain area in the reward pathway and one involved in memory. Source: Used with permission of Guillaume L. Poirier. Mentholated cigarettes account for about a quarter of the U.S. market, and appeal particularly to adolescents.
What does menthol do to your skin?
Menthol provides a cooling sensation when applied to the skin, which helps relieve pain in the tissues underneath the skin. Menthol topical (for use on the skin) is used to provide temporary relief of minor arthritis pain, backache, muscles or joint pain, or painful bruises.
What is the function of TRPM8 in acute pain?
TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pirt regulates the function of TRPM8 and its role in detecting cold. External cooling-induced shivering and tachycardia are not suppressed by TRPM8 inhibition.
Which is the best model for TRPM8 sensitization?
Numerous studies have been published investigating the effect of L-menthol application as a model for TRPM8-sensitization. The primary consensus finding is that TRPM8 sensitization increases the sensation of cold pain, also known as cold hyperalgesia.
What is the role of TRPM8 in the Cold Response?
We found that artemin, the specific GFRalpha3 ligand that evokes heat hyperalgesia, robustly sensitized cold responses in a TRPM8-dependent manner in mice. These results demonstrate that TRPM8 is a novel regulator of serum insulin and support the role of sensory innervation in metabolic homeostasis.
What are the antagonists of the TRPM8 receptor?
Antagonists BCTC, thio-BCTC, capsazepine and M8-An were identified as antagonists of the TRPM8 receptor. These antagonists physically block the receptor for cold and menthol, by binding to the S1-S4 voltage-sensing domain, preventing response. PF-05105679 cas: [1398583-31-7].