What is the defect in Gilbert syndrome?

Published by Charlie Davidson on

What is the defect in Gilbert syndrome?

Gilbert’s syndrome is an inherited (genetic) liver disorder that affects the body’s ability to process bilirubin. Bilirubin is yellow liquid waste that occurs naturally as the body breaks down old red blood cells. People with Gilbert’s syndrome don’t produce enough liver enzymes to keep bilirubin at a normal level.

Which enzyme is deficient in Gilbert syndrome?

Gilbert’s syndrome is a genetic condition that’s passed down from your parents. It’s caused by a mutation in the UGT1A1 gene. This mutation results in your body creating less bilirubin-UGT, an enzyme that breaks down bilirubin. Without proper amounts of this enzyme, your body can’t process bilirubin correctly.

What is usually elevated in Gilbert’s syndrome?

The most frequent sign of Gilbert’s syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of the slightly elevated levels of bilirubin in the blood.

Which bilirubin is elevated in Gilbert’s syndrome?

Gilbert syndrome is characterized by elevated serum bilirubin, specifically unconjugated bilirubin due to a deficiency of bilirubin glucoronidation (11).

What foods to avoid if you have Gilbert’s syndrome?

Most animal products (meat, eggs, dairy) should be eaten sparingly, as should aged or fermented products such as bread, beer, cheese, wine, cured meats, and tobacco. Aspirin should be avoided altogether. Including plenty of fresh fruits and vegetables will help during this period of healing and repair.

How can I lower my bilirubin in Gilbert’s syndrome?

These steps include:

  1. Make sure your doctors know you have Gilbert’s syndrome. Because Gilbert’s syndrome affects the way your body processes certain medications, every doctor you visit needs to know that you have the condition.
  2. Eat a healthy diet. Avoid extremely low-calorie diets.
  3. Manage stress.

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