What is the drug of choice for pregnancy induced hypertension?

Published by Charlie Davidson on

What is the drug of choice for pregnancy induced hypertension?

Methyldopa remains one of the most widely used drugs for the treatment of hypertension in pregnancy.

Why is labetalol preferred in pregnancy?

The combined and ß-adrenoceptor blocker labetalol is a peripheral vasodilator which has been shown to be effective in pre-eclamptic and non-proteinuric hypertension in pregnancy. Available data suggest that the antihypertensive effect is not associated with compromised renal or uterine blood flow.

Do labetalol and methyldopa have different effects on pregnancy outcome?

Methyldopa (versus labetalol) postrandomisation was associated with fewer CHIPS primary outcomes (aOR 0.64; 95% CI 0.40-1.00), birthweight <10th centile (aOR 0.54; 95% CI 0.32-0.92), severe hypertension (aOR 0.51; 95% CI 0.31-0.83), pre-eclampsia (aOR 0.55; 95% CI 0.36-0.85), and delivery at <34 weeks (aOR 0.53; 95% CI …

Why is amlodipine not used in pregnancy?

Amlodipine falls into category C. There are no good studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if amlodipine will harm your unborn baby.

Is labetalol safe in pregnancy?

If your doctor recommends labetalol during your pregnancy, they’ll prescribe the lowest dose that works for you. Labetalol is not thought to harm an unborn baby. But there’s a small chance that when your baby’s born the medicine can affect their blood sugar levels.

What is the safest beta blocker in pregnancy?

There is a general consensus that labetalol is safer than other β-blockers during pregnancy, and this drug is rapidly becoming the first-line choice in conditions, such as chronic hypertension during pregnancy.

How does labetalol work in pregnancy?

If you’re pregnant, labetalol is the first choice for treating high blood pressure. Labetalol works on the heart and on blood vessels. Other beta blockers, such as bisoprolol, work mainly on the heart. There are several other medicines to lower blood pressure and treat chest pain.

Is amlodipine bad for pregnancy?

Amlodipine and Pregnancy Amlodipine falls into category C. There are no good studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if amlodipine will harm your unborn baby.

Which is better methyldopa or labetalol for pregnancy?

1 Department of Obstetrics and Gynecology, Al-Jahra Hospital, Jahra, Kuwait. Objective: To assess the efficacy and safety of labetalol compared with methyldopa in the management of mild and moderate cases of pregnancy-induced hypertension (PIH).

How often should I take labetalol or methyldopa?

Methods: One hundred four primigravidas with PIH were randomly allocated to receive either labetalol (group A) or methyldopa (group B). The dose of the drugs was doubled every 48 h to maintain a mean arterial blood pressure < or = 103.6 mmHg. Clinico-biochemical effects and frequency of side effects were studied.

Are there any side effects to taking labetalol?

Tolerance does not develop during therapy [14]. The main side effects oflabetalol are fatigue, headache, postural hypotension, gastrointestinal symptoms (if it is used in high doses), and it can worsen bronchial asthma [15]. In the current study, we compared the efficacy and safety of labetalol with methyldopa.

Which is the best drug to take for hypertension in pregnancy?

However, there is evidence that intravenous labetalol or oral nifedipine are preferable first-line agents compared to intravenous hydralazine in severe hypertension in pregnancy [37]. Sodium nitroprusside is rarely used in pregnancy and is reserved for life-threatening severe hypertension [42].

Categories: Popular lifehacks