Which PPI is safe with clopidogrel?

Published by Charlie Davidson on

Which PPI is safe with clopidogrel?

So, which PPIs are safe to use with Plavix? Currently, the manufacturer of Plavix recommends using pantoprazole (Protonix), lansoprazole (Prevacid), or Dexilant (dexlansoprazole). In their research, these three PPIs had the least effect on the effectiveness of Plavix.

Why omeprazole should be avoided in patient using clopidogrel?

In conclusion, even though pharmacodynamic studies suggest that omeprazole can attenuate the antiplatelet effect of clopidogrel, this interaction does not appear to translate into increased cardiovascular risk in patients treated with this combination. Other PPIs also do not appear to interact with clopidogrel.

Is omeprazole safe to take with clopidogrel?

Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable.

Why clopidogrel is contraindicated when co administered with PPIs?

This review followed the publication of studies suggesting concomitant use of proton pump inhibitors can reduce the efficacy of clopidogrel. Clopidogrel inhibits platelet aggregation and is indicated for the prevention of vascular ischaemia associated with atherothrombotic events.

What drugs should not be taken with clopidogrel?

Clopidogrel may interact with other medications

  • Diabetes drug. In most cases, repaglinide should not be taken with clopidogrel.
  • Stomach acid drugs (proton pump inhibitors)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Blood thinners.
  • Drugs used to treat depression.
  • Salicylates (aspirin)
  • Opioids.

What antacid can I take with clopidogrel?

The FDA advises that if you are experiencing heartburn or acid reflux while taking Plavix, you should try using antacids ( Maalox, Mylanta, Rolaids, Tums and generics) and most H2 blockers such as famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac), but not cimetidine (Tagamet, Tagamet HB, and generics).

What foods should I avoid while taking clopidogrel?

Is there any food or drink I need to avoid? Do not drink grapefruit juice while taking clopidogrel. Grapefruit juice decreases the effects of your medicine, so that it may not work as well to prevent clots.

Does clopidogrel affect blood pressure?

You likely won’t have blood pressure changes while you’re taking Plavix. However, sudden drops in blood pressure may be a symptom of serious internal bleeding, which is a possible side effect of Plavix.

What foods to avoid if you are on blood thinners?

5 Things to Avoid If You’re On Blood Thinners

  • Leafy greens. Leafy greens like kale, spinach, Brussels sprouts and lettuce contain high amounts of vitamin K.
  • Green tea.
  • Cranberry juice.
  • Grapefruit.
  • Alcohol.

Can a proton pump inhibitor be used with clopidogrel?

In light of the most recent evidence, the previous advice on the concomitant use of clopidogrel with proton pump inhibitors has now been modified. Use of either omeprazole or esomeprazole with clopidogrel should be discouraged.

Are there any cases of Acquired haemophilia with clopidogrel?

Although no cases had a fatal outcome, two were considered life-threatening. Although these events are very rare, it is important to be aware of the possibility that a patient may develop acquired haemophilia, as distinct from the risk of bleeding associated with clopidogrel.

What happens if you take aspirin with clopidogrel?

A retrospective study 9 of cardiovascular and gastrointestinal outcome in patients on clopidogrel and aspirin with and without gastroprotective agents found that although PPI use was associated with an increase in adverse cardiovascular events, it was also associated with a significantly reduced incidence of upper GI bleeding.

When to use clopidogrel and Plavix together?

Clopidogrel is indicated for the prevention of atherothrombotic events in patients who have had a myocardial infarction or ischaemic stroke, or who have established peripheral arterial disease. Combined with aspirin, the brand leader product (Plavix) may also be used to prevent atherothrombotic events in patients with acute coronary syndrome.

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