Is urokinase a plasminogen activator?

Urokinase-Type Plasminogen Activator (uPA) The “Urokinase-type Plasminogen Activator” or simply “urokinase” (uPA) is a key serine protease involved in the conversion of inactive plasminogen into active plasmin, which in turn functions in a range of events of the metastatic cascade (23).

What is soluble urokinase plasminogen activator receptor?

Soluble urokinase plasminogen activator receptor is a receptor released from cell membrane‐bound uPAR, and existing evidence illustrates that suPAR is involved in various inflammatory‐related diseases such as acute liver failure, sepsis, systemic inflammatory response syndrome, and lupus nephritis.

What is the function of urokinase?

Urokinase is a thrombolytic enzyme predominantly formed in the kidney and excreted in the urine. The enzyme converts plasminogen into plasmin and promotes the dissolution of physiologically-occurring blood clots; for example, as in menstrual blood.

What is the mechanism of action of urokinase?

Urokinase is a physiologic thrombolytic agent that is produced in renal parenchymal cells. Unlike streptokinase, urokinase directly cleaves plasminogen to produce plasmin. When it is purified from human urine, approximately 1500 L of urine is needed to yield enough urokinase to treat a single patient.

Is urokinase made from urine?

Urokinase is a trypsin-like1 enzyme that is produced endogenously by renal parenchymal cells30 and found in urine. Approximately 1500 L of urine are needed to yield enough urokinase to treat a single patient.

Is urokinase an anticoagulant?

Consequently, the administration of urokinase as a sole anticoagulant results in activation of coagulation and fibrinolysis, and, as a result, induces disseminated intravascular coagulation.

What is plasma SuPAR?

SuPAR is the soluble form of urokinase plasminogen activator receptor (uPAR), a receptor mainly expressed on various immunologically active cells such as macrophages, neutrophils, and activated T lymphocytes, as well as on endothelial cells [1].

What type of drug is urokinase?

Protein
Urokinase/Classification

Is urokinase a drug?

Urokinase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a “clot-busting” drug. It helps your body produce a substance that dissolves unwanted blood clots. Urokinase is used to treat blood clots in the lungs. Urokinase may also be used for purposes not listed in this medication guide.

How is urokinase-type plasminogen activator receptor ( uPAR ) regulated in cancer cells?

Urokinase-type plasminogen activator receptor (uPAR)-mediated regulation of WNT/β-catenin signaling is enhanced in irradiated medulloblastoma cells Urokinase plasminogen activator receptor (uPAR) is known to promote invasion, migration, and metastasis in cancer cells.

What kind of receptor is the urokinase receptor?

Urokinase receptor. The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 ( C luster of D ifferentiation 87 ), is a protein encoded in humans by the PLAUR gene.

What are the homologous domains of the uPAR receptor?

The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane receptor, composed by three homologous domains (DI, DII, DIII).

What are the three finger domains of urokinase?

uPAR consists of three different domains of the three-finger protein domain family, which also includes domains found in lymphocyte antigen 6 and in snake venom toxins of the three-finger toxin family, such as alpha-neurotoxins. All three three-finger domains are necessary for high affinity binding of the primary ligand, urokinase.