What is familial Mediterranean?

Published by Charlie Davidson on

What is familial Mediterranean?

Summary. Familial Mediterranean fever (FMF) is an inherited autoinflammatory disease characterized by recurrent episodes (attacks) of fever and acute inflammation of the membranes lining the abdomen, joints, and lungs.

How common is familial Mediterranean fever?

Familial Mediterranean fever primarily affects populations originating in the Mediterranean region, particularly people of Armenian, Arab, Turkish, or Jewish ancestry. The disorder affects 1 in 200 to 1,000 people in these populations. It is less common in other populations.

Is familial Mediterranean fever dominant or recessive?

Familial Mediterranean fever (FMF) is classically an autosomal recessive periodic inflammatory disease occurring in Mediterranean and Middle Eastern populations. It is caused by mutations affecting both alleles of MEFV, a gene that encodes pyrin (marenostrin), an uncharacterized neutrophil protein.

How do you relieve pain from FMF?

It is treated with bed rest and nonsteroidal anti-inflammatory agents. Almost all patients with FMF present with painful abdominal attacks. The pain and tenderness initially may be focal, usually the lower abdomen, but then progress to become more generalized. The pain is so severe that it resembles peritonitis.

What are the symptoms of FMF?

Signs and symptoms of familial Mediterranean fever include:

  • Fever.
  • Abdominal pain.
  • Chest pain.
  • Achy, swollen joints.
  • A red rash on your legs, especially below your knees.
  • Muscle aches.
  • A swollen, tender scrotum.

Is familial Mediterranean fever fatal?

Familial Mediterranean fever is an inherited autoinflammatory syndrome characterised by recurrent short episodes of high fever associated with abdominal pain, inflammation of joints and other body sites and skin rash. If untreated, amyloidosis commonly develops and may have a fatal outcome.

How painful is familial Mediterranean fever?

FMF often causes fever attacks that may last for up to 3 days. Fevers can spike up to 104 degrees. Along with a fever, it can cause joint pain and swelling, typically in the knee or ankle. A child’s joint may be so painful and swollen that they can’t walk.

Can Familial Mediterranean Fever be cured?

There’s no cure for familial Mediterranean fever. However, treatment can help prevent signs and symptoms. Medications used to control signs and symptoms of familial Mediterranean fever include: Colchicine.

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