Can neuroendocrine cancer spread to the prostate?

Small cell prostate carcinoma (SCPC) is a rare form of extrapulmonary high-grade neuroendocrine carcinoma accounting for <0.5% to 1% of all prostate cancers (1).

What is the differentiation in prostate cancer?

Neuroendocrine differentiation (NED) in prostate cancer is a well-recognized phenotypic change by which prostate cancer cells transdifferentiate into neuroendocrine-like (NE-like) cells. NE-like cells lack the expression of androgen receptor and prostate specific antigen, and are resistant to treatments.

Is neuroendocrine cancer the same as colon cancer?

Neuroendocrine carcinoma (NEC) of colon and rectum is a rare neuroendocrine tumor (NET) type that accounts for < 1% of all colorectal malignancies[1]. The clinical progression of NECs includes highly aggressive growth and rapid dissemination along with a high tendency for metastasis[2].

What is the survival rate for metastatic neuroendocrine cancer?

The 5-year survival rate for people with pancreatic NET that has not spread to other parts of the body from where it started is 93%. If the tumor has spread to nearby tissue or the regional lymph nodes, the 5-year survival rate is 77%. If the tumor has spread to distant areas of the body, the survival rate is 25%.

Is small cell prostate cancer hereditary?

Genetics. Some prostate cancers may have a genetic component. There is a 10-fold increased relative risk for patients with 2 or more affected first-degree relatives. A patient with a first-degree relative with prostatic adenocarcinoma has a 2-fold increased relative risk.

What is Neuroendocrine prostate cancer?

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises de novo only rarely; the disease predominantly develops from adenocarcinoma in response to drug-induced androgen receptor signalling inhibition, although the mechanisms behind this transdifferentiation are a subject of debate.

How aggressive is neuroendocrine cancer?

High-grade large cell and small cell neuroendocrine tumors are aggressive. These tumors tend to grow rapidly and invade other tissues. Carcinoid tumors of the colon are considered indolent. They tend to be slower growing and less invasive than large cell and small cell neuroendocrine tumors.

How long do you live with neuroendocrine cancer?

Around 90 out of 100 people (around 90%) survive for 1 year or more. Around 89 out of every 100 people (around 89%) people survive for 5 years or more. This 5 year survival rate was taken from a European study that looked at 270 people diagnosed with a gut neuroendocrine tumour between 1984 and 2008.

How long can you live with neuroendocrine cancer?

The median survival duration was 41 months. The 1-, 3-, 5-, and 10-year overall survival rates for patients with NETs were 72.8%, 52.7%, 39.4%, and 18.1%, respectively.

How is neuroendocrine differentiation used to treat prostate cancer?

Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies

Can you get neuroendocrine carcinoma of the prostate?

Although a de novo clinical presentation of small cell neuroendocrine carcinoma of the prostate is rare, a subset of patients previously diagnosed with prostate adenocarcinoma may develop neuroendocrine features in later stages of castration-resistant prostate cancer (CRPC) progression as a result of treatment resistance.

Is there a neuroendocrine response to PSMA?

Neuroendocrine Differentiation and Response to PSMA-Targeted Radioligand Therapy in Advanced Metastatic Castration-Resistant Prostate Cancer: A Single-Center Retrospective Study. Derlin T, Werner RA, Lafos M, Henkenberens C, von Klot CAJ, Sommerlath Sohns JM, Ross TL, Bengel FMJ Nucl Med2020 Nov;61(11):1602-1606.