What does CD103 do?

Published by Charlie Davidson on

What does CD103 do?

CD103 can bind, paired with the β7 chain, to E-cadherin (21). E-Cadherin is expressed on a variety of cell types, including intestinal epithelial cells, keratinocytes, and Langerhans cells, an epidermal APC subset (22–24).

What is CD 103?

CD103 / cluster of differentiation 103, also known as Integrin, alpha E (ITGAE), is an integrin protein that in human is encoded by the ITGAE gene. CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name.

What is CD11b a marker for?

CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.

What are CD103+ dendritic cells?

Dendritic cells are essential modulators of the immune system as they maintain the balance between immunogenic and tolerogenic immune responses in the intestine. CD103+ DCs may provide a novel therapeutic target to induce the expansion of Treg cells in the intestine.

What is CD11c a marker for?

DCs bearing CD11c surface markers are potent antigen-presenting cells that reside in the skin and other tissues. DCs bridge innate and adaptive immunity, and by modulating T cell, B cell, and monocyte/macrophage function, they shape the immune response (see Figure 83-9).

What is F4 80 cells?

F4/80 antigen is a mature mouse cell surface glycoprotein expressed at high levels on various macrophages including: Kupffer cells, splenic red pulp macrophages, microglia, gut lamina propria, and Langerhans cells in the skin.

Do macrophages express CD11c?

It is now recognized that several non-DC myeloid populations express CD11c, including alveolar macrophages and resident (Ly6C low) monocytes and that some macrophage populations express both CD11c and MHC class II [8, 9]. Similarly, CD11b has often been used as a marker for all myeloid cell types.

Is CD3 and antibody?

An anti-CD3 monoclonal antibody is one that binds to CD3 on the surface of T cells. They are immunosuppresive drugs. The first to be approved was muromonab-CD3 in 1986, to treat transplant rejection. Newer monoclonal antibodies with the same mechanism of action include otelixizumab, teplizumab and visilizumab.

Is CD3 at cell marker?

CD3 is expressed by a high-percentage of circulating peripheral T cells forming a complex with the T cell receptor (TCR). As CD3 is present at all stages of T cell development, it is a highly effective T cell marker.

Where does CD103 antibody stain bone marrow cells?

CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

What is the alpha chain of CD103 antibody?

In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes.

What happens to resident CD103 + CD8 + T cells?

There is a reduction in resident CD103 + CD8 + T cells following primary infection that results in increased susceptibility of the host to secondary infection. Intriguingly, CD103 expression inversely and specifically correlates with SKI proto-oncogene (SKI) expression but not R-Smad2/3 activation.

How does CD103 interact with beta 7 integrin?

In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.

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