Does Protonix interfere with Plavix?

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Does Protonix interfere with Plavix?

So, which PPIs are safe to use with Plavix? Currently, the manufacturer of Plavix recommends using pantoprazole (Protonix), lansoprazole (Prevacid), or Dexilant (dexlansoprazole). In their research, these three PPIs had the least effect on the effectiveness of Plavix.

Does Protonix interfere with blood thinners?

Pantoprazole is commonly used in Pediatric Intensive Care Unit (ICU) for prophylaxis of stress-induced ulcers. It probably can interact with warfarin and further prolong INR, which can result in life-threatening bleeding.

Which PPI should be avoided with clopidogrel?

1 FDA-approved labeling recommends avoiding concurrent use of the PPIs omeprazole and esomeprazole with clopidogrel.

What happens when clopidogrel is given with a PPI?

Proton pump inhibitors are inhibitors of CYP2C19 with varying degrees of potency. Therefore, PPIs may inhibit activation of clopidogrel to its active metabolite via CYP2C19 leading to decreased serum concentrations of the active metabolite and potentially reducing the antiplatelet effect of clopidogrel.

What foods should you avoid when taking Plavix?

Foods to avoid when taking heart medications

  • Asparagus.
  • Broccoli.
  • Brussels sprouts.
  • Cauliflower.
  • Green onions.
  • Kale.
  • Parsley.
  • Spinach.

What can you not take with Plavix?

Nov. 17, 2009 – The FDA today warned patients not to combine Plavix with Nexium, Prilosec, and nine other drugs — including Prozac and Tagamet. The drugs may make the anti-clotting drug Plavix dangerously less effective, the FDA says.

Is it safe to take omeprazole with clopidogrel?

Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable.

Can you eat salad while taking Plavix?

So, in answer to the original question, no, it isn’t necessary to avoid green vegetables because the Vitamin K they contain enables a better control of both coagulation and medication.

What foods should you avoid if you are on clopidogrel?

Is there any food or drink I need to avoid? Do not drink grapefruit juice while taking clopidogrel. Grapefruit juice decreases the effects of your medicine, so that it may not work as well to prevent clots.

Can a proton pump inhibitor make Plavix less effective?

PPIs can make Plavix less effective, potentially raising your risk of a heart attack or stroke. Certain PPIs may be of more concern than others. There are other options available for heartburn if PPIs do not work well for you, but it is best to discuss the most appropriate alternative for you with your provider if you take Plavix.

Can a proton pump inhibitor reduce clopidogrel efficacy?

Thus, the results of this trial demonstrate the lack of interaction between either pantoprazole or esomeprazole and clopidogrel, and, therefore, there does not appear to be a reduction in clopidogrel efficacy with the concomitant utilization of these two specific PPIs.

When to use a proton pump inhibitor ( PPI )?

Clopidogrel (Plavix®) is a widely used anti-platelet agent that is commonly combined with aspirin to reduce the risk of various cardiovascular events. Because of the associated increased risk of gastrointestinal bleeding with this combination, a proton pump inhibitor (PPI) is often prescribed during such therapy.

Is it safe to take Plavix with omeprazole?

Click to see full answer. Correspondingly, which PPI is safe with Plavix? However, if a PPI is selected, one should exercise caution when using omeprazole, rabeprazole, or lansoprazole and clopidogrel concomitantly.

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