What is a fetal antigen?

Published by Charlie Davidson on

What is a fetal antigen?

Fetal antigens are detected by maternal T cells through interactions with antigen-presenting cells in pregnancy.

What does it mean if you have antibodies in your blood when pregnant?

Rhesus disease is a condition where antibodies in a pregnant woman’s blood destroy her baby’s blood cells. It’s also known as haemolytic disease of the foetus and newborn (HDFN). Rhesus disease doesn’t harm the mother, but it can cause the baby to become anaemic and develop jaundice.

Can antigens pass through the placenta?

Although only IgG anti-A and anti-B can cross the placenta, these antibodies are found in the circulation of most newborn infants born to blood group O mothers. The A and B antigens are much weaker on the red blood cell of newborn infants than of adults.

What antigens are present at birth?

If present at birth, anti-A and anti-B are IgG and of maternal origin. The antibodies develop between 3 – 6 months of age due to unknown antigenic stimuli, presumably bacteria and foodstuffs. They reach their highest level between 5 – 10 years of age, remain fairly constant in adulthood, and slowly decline in old age.

Is there any importance for antigen in pregnancy?

Pregnancy induces priming of the maternal cellular and humoral immune system. The paternally-inherited fetal antigens that influence maternal T and B cells include both major and minor histocompatibility antigens – the same antigens that are problematic in allotransplantation.

Why is the immune system weaker during pregnancy?

Despite these protective mechanisms, you’re more prone to infections that don’t normally cause illness. During pregnancy, your immune system has to work harder since it’s supporting two. This makes you susceptible to certain infections.

Are antibodies bad for pregnancy?

Antibodies are generally harmless, but they can move from your blood stream into your baby’s blood. Your baby’s red cells could be damaged if they have the blood group which matches these antibodies.

What does positive antibodies mean in pregnancy?

An RBC (red blood cell) antibody screen is a blood test that looks for antibodies that target red blood cells. Red blood cell antibodies may cause harm to you after a transfusion or, if you are pregnant, to your baby. An RBC antibody screen can find these antibodies before they cause health problems.

Why is a fetus not considered antigen?

The researchers discovered that embryo implantation sets off a process that ultimately turns off a key pathway required for the immune system to attack foreign bodies. As a result, immune cells are never recruited to the site of implantation and therefore cannot harm the developing fetus.

What blood group should not marry?

In general: If you have type A blood, you should only receive types A or O blood. If you have type B blood, you should only receive types B or O blood. If you have type AB blood, you can receive types A, B, AB, or O blood.

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