How was kisspeptin discovered?

Published by Charlie Davidson on

How was kisspeptin discovered?

A major breakthrough in the initial discovery of kisspeptin came when the ligand of an orphan GPCR, OT7T175, which is nearly identical to AXOR12 and GPR54, was identified.

What is kisspeptin used for?

Kisspeptin, made in the hypothalamus, is an important hormone that starts the release of several other hormones. Also called metastin, this interesting hormone is connected to puberty and may also help stop the spread of cancer.

Where did kisspeptin get its name?

It was discovered in a town called Hershey, Pennsylvania, where there’s also a massive factory where they make Hershey’s chocolates, in particular the little chocolates they call Hershey’s kisses, hence the name, kisspeptin.

Where is kisspeptin found?

hypothalamus
Kisspeptin is produced from the hypothalamus and causes a cascade of cell-cell communication, ultimately leading to the production of the hormones, luteinising hormone and follicle stimulating hormone from the pituitary gland, which are released into the blood.

Does kisspeptin increase testosterone?

Conclusions: Kisspeptin-10 boluses potently evoke LH secretion in men, and continuous infusion increases testosterone, LH pulse frequency, and pulse size. Kisspeptin analogues have therapeutic potential as regulators of LH and thus testosterone secretion.

Does kisspeptin have side effects?

Kisspeptin has now been administered to humans in both the KP-10 and KP-54 isoforms. All of the studies so far have shown it to be safe for use in humans with no demonstrable side effects.

Why do men kisspeptin?

Increased activity of the hormone, kisspeptin, enhances sexual attraction and decreases anxiety in male mice, according to new research presented today at the Society for Endocrinology annual conference in Harrogate.

How long does it take for kisspeptin-10 to work?

Intravenous injections of kisspeptin-10 elicited a rapid increase in LH in all volunteers, with peak concentrations seen by 45 min after injection for all doses studied. The maximum LH stimulation was seen after the 1-μg/kg bolus, achieving peak (12.4 ± 1.7 IU/liter) concentration at 30 min (Fig. 1A).

How quickly does kisspeptin work?

Is kisspeptin better than hCG?

Kisspeptin administration significantly increased human chorionic gonadotropin (hCG)-stimulated testosterone levels in acycline treated monkeys compared to hCG treatment alone (17) suggesting that kisspeptin might enhance LH responses in Leydig cells.

Does HCG burn fat or muscle?

Taking hCG puts the body in an anabolic state that is conducive to building muscle and burning fat. When your body is in starvation mode due to caloric restrictions, hCG allows the body to burn unwanted fat instead of burning muscle, so the weight that is lost during the diet is mostly fat.

Where does the hormone kisspeptin come from?

Kisspeptin is produced from the hypothalamus and causes a cascade of cell-cell communication, ultimately leading to the production of the hormones, luteinising hormone and follicle stimulating hormone from the pituitary gland, which are released into the blood.

What happens if you dont have kisspeptin in your body?

Those neurotransmitters then signal the release of luteinizing hormone and follicle stimulating hormone. These hormones have a role to play in the production of testosterone and oestradiol. Without kisspeptin, this entire chain reaction would be damaged.

What can kisspeptin be used for in the future?

Kisspeptin has now been safely and successfully used in both men and women, it is possible that in the future the manipulation of kisspeptin signaling may be used in the treatment of reproductive disorders.

What are the half lives of kisspeptin 10?

Despite administration of equimolar amounts, peak levels of kisspeptin-10 in the bloodstream are almost 50-times lower than after administration of kisspeptin-54 ( De Tassigny et al., 2017 ). Using the decay curve of kisspeptin immunoreactivity, the half-lives of both isoforms have been calculated.

Categories: Trending